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In this regard, Griemstein and colleagues have demonstrated the potential utility of A1AT in RA using a murine model

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doi: 10.1038/emi.2017.54 117 BurbeloPDKellerJWagnerJKlimaviczJSBayatARhodesCSet al

In addition, PLGA allows surface modifications (e.g., aptamers, antibodies, hyaluronic acid), enabling tumor-specific accumulation and reduced systemic side effects key for chemo resistant metastatic CRC cases